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KMID : 1123920220360010018
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Korean Journal of Oriental Physiology and Pathology
2022 Volume.36 No. 1 p.18 ~ p.22
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Effects of Chronic Treatment of Taegeuk Ginseng on Cognitive Function Improvement in Scopolamine Induced Memory Retarded Rats
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Lee Cheol-Hyeong
Park Ji-Hye
Kim Kyu-Il
Lee Seoul
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Abstract
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To investigate effects of cognitive function improvement whether against Taegeuk ginseng on scopolamine-induced memory impairment in rats. All experiments were conducted in three groups: the control group (CTR), the scopolamine 0.4mg/kg (SCP), and the scopolamine (SCP+T) treated with Taegeuk ginseng 100 mg/kg. Taegeuk ginseng 100 mg/kg daily was orally administered for one month and treated with scopolamine was only for 7 consecutive days on the Morris water maze task. 3 weeks after oral administration of Taegeuk ginseng, subjects were performed the Morris water maze test for 8 days and then the open-field exploration test which to assessed for cognitive function improvement. After behavioral testing, subjects were sacrificed and microdissected brains for neurochemical analysis. In the cognitive-behavioral test, long-term administration of Taegeuk ginseng improved spatial navigation learning task compared with the impeded by scopolamine treatment. In neurochemistry, the expression of the synaptic marker PSD95 (postsynaptic density protein 95) was increased in the hippocampus compared to the scopolamine group. Also, brain-derived neurotrophic factor (BDNF) expression was significantly increased in the taegeuk ginseng administration group. These data suggested that long-term administration of taegeuk ginseng might improve cognitive-behavioral functions on hippocampal related spatial learning memory, and it was correlated with neurotropic and synaptic reinforcement. In conclusion, treatment with taegeuk ginseng may positive outcome on learning and memory deficit disorders.
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KEYWORD
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Postsynaptic density protein 95 (PSD95), Brain-derived neurotrophic factor (BDNF), Scopolamine, Morris water maze, Rat, Exploration, Spatial navigation learning, Cognitive function
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